Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356861 | 0.92 | KDM4E (0.46) | MAPTALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL17731988 | 0.92 | KDM4E (0.46) | MAPTALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL25810589 | 0.89 | HDAC8 (0.49) | ALDH1A1KDM4ERAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL25252447 | 0.84 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6608349 | 0.83 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL16713302 | 0.83 | CYP1A2 (0.50) | MAPTALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL23838039 | 0.83 | PKM (0.56) | ALDH1A1L3MBTL1 | |
| SCHEMBL18741349 | 0.82 | L3MBTL1 (0.46) | ALDH1A1L3MBTL1PPARDPPARALMNA | |
| SCHEMBL4844769 | 0.82 | KDM4E (0.53) | MAPTALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL20898309 | 0.81 | MAPT (0.60) | MAPTALDH1A1RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3882246-A1 | MONOBACTAM COMPOUNDS AND USE THEREFOR | Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020098635-A1 | MONOBACTAM COMPOUNDS AND USE THEREFOR | 南京圣和药业股份有限公司 | 2020-05-22 | — | — | WO | disclosed |