Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 12/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21997022 | 0.89 | PIK3CA (0.45) | KMT2AKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL29948104 | 0.89 | PIK3CA (0.45) | KMT2AKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL22013653 | 0.83 | MAP4K4 (0.51) | MAP4K4MELKNPC1 | |
| SCHEMBL29918750 | 0.76 | PSMD14 (0.43) | KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL21997997 | 0.76 | PSMD14 (0.43) | KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL29948108 | 0.75 | L3MBTL1 (0.45) | KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL21998273 | 0.75 | L3MBTL1 (0.45) | KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL21997740 | 0.75 | ATR (0.46) | KMT2AKDM4EMEN1ALDH1A1NPC1 | |
| SCHEMBL29918790 | 0.75 | ATR (0.46) | KMT2AKDM4EMEN1ALDH1A1NPC1 | |
| SCHEMBL23836983 | 0.75 | MAP4K4 (0.54) | MAP4K4KDM4EALDH1A1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3882247-A1 | SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR | Shanghai Ennovabio Pharmaceuticals Co., Ltd. (CN) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020098723-A1 | SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR | 上海轶诺药业有限公司 | 2020-05-22 | — | — | WO | disclosed |