Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28874019 | 0.77 | TSHR (0.46) | MAPTALDH1A1TDP1TSHRTP53 | |
| SCHEMBL16675141 | 0.77 | HDAC6 (0.44) | HDAC6HDAC1MAPTALDH1A1TDP1 | |
| SCHEMBL279615 | 0.76 | ALDH1A1 (0.45) | MAPTALDH1A1TDP1TSHRTP53 | |
| SCHEMBL279614 | 0.76 | ALDH1A1 (0.45) | MAPTALDH1A1TDP1TSHRTP53 | |
| SCHEMBL18294910 | 0.74 | ALDH1A1 (0.45) | HDAC6HDAC1MAPTALDH1A1TDP1 | |
| SCHEMBL10330363 | 0.71 | IDO1 (0.46) | MAPTALDH1A1TDP1FAAHMGLL | |
| SCHEMBL13681219 | 0.71 | TSHR (0.40) | MAPTALDH1A1TDP1TSHRTP53 | |
| SCHEMBL19675175 | 0.71 | TSHR (0.40) | MAPTALDH1A1TDP1TSHRTP53 | |
| SCHEMBL10973834 | 0.70 | KDR (0.45) | ALDH1A1TDP1NPC1RAB9APDGFRB | |
| SCHEMBL4582422 | 0.70 | TDP1 (0.54) | HDAC6HDAC1MAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10660890-B2 | Treatment of polycystic diseases with an HDAC6 inhibitor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR) (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10660890-B2 | Treatment of polycystic diseases with an HDAC6 inhibitor | HDAC6, PKD1, PKD2 | HDAC6 1/4885HDAC1 4/4885MAPT 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.