SCHEMBL22014316

SCHEMBL22014316

COP(=O)(CN1CCN(CP(=O)(OC)c2ccccc2)CCN(CP(=O)(OC)c2ccc(-c3cccc(P(=O)(O)CN4CCN(CP(=O)(O)c5ccccc5)CCN(CP(=O)(O)c5ccccc5)CC4)c3)cc2)CC1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
KMT2A Q03164 2/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
RECQL P46063 1/20 0.35
BACE1 P56817 1/20 0.35
POLB P06746 1/20 0.34
CFTR P13569 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
GGPS1 O95749 1/20 0.34
DRD4 P21917 1/20 0.34
USP2 O75604 2/20 0.34
HSD17B10 Q99714 2/20 0.34
CYP1A2 P05177 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP2C19 P33261 1/20 0.34
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22014315 0.80 AOX1 (0.41) MEN1KMT2ALMNAPOLBCYP2C19
SCHEMBL22014317 0.75 CFTR (0.57) MEN1ALDH1A1KMT2ACFTRCYP1A2
SCHEMBL22014100 0.73 AOX1 (0.37) LMNAPOLBCYP2C19CYP3A4KYNU
SCHEMBL22014312 0.72 SIGMAR1 (0.53) KDM4EMEN1ALDH1A1KMT2ALMNA
SCHEMBL22014482 0.71 CFTR (0.52) MEN1ALDH1A1KMT2ACFTRCYP1A2
SCHEMBL22014092 0.71 CFTR (0.52) MEN1ALDH1A1KMT2ACFTRCYP1A2
SCHEMBL21961918 0.69 CFTR (0.48) MEN1ALDH1A1KMT2ACFTRCYP1A2
SCHEMBL22014093 0.68 SIGMAR1 (0.58) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL22014308 0.65 CFTR (0.41) KDM4EMEN1ALDH1A1KMT2ALMNA
SCHEMBL19444838 0.63 HDAC8 (0.46) MEN1KMT2ALMNAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020102820-A1 COMPOUNDS FOR USE AS IRON (III) MRI CONTRAST AGENTS CONTAINING ANIONIC PENDENTS AND ANCILLARY GROUPS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2020-05-22 WO disclosed