Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FABP2 | P12104 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15856377 | 0.82 | METAP2 (0.46) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL20754892 | 0.81 | METAP2 (0.37) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL20912008 | 0.78 | ALDH1A1 (0.43) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL23419417 | 0.78 | PTGS1 (0.39) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL23046908 | 0.77 | PTGS1 (0.42) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL20634961 | 0.76 | CA1 (0.35) | LMNA | |
| SCHEMBL22374010 | 0.76 | CCNC (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20754729 | 0.73 | PTGS1 (0.35) | METAP2PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL21962584 | 0.73 | NLRP3 (0.42) | PTGS1MEN1PTGS2KMT2AFABP2 | |
| SCHEMBL30933569 | 0.73 | ESR2 (0.42) | METAP2PTGS1MEN1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |