Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597569 | 0.90 | CYP4F2 (0.38) | CYP4F2CYP4A11OPRM1SLC22A1SLC6A4 | |
| SCHEMBL16508898 | 0.85 | OPRM1 (0.40) | CYP4F2CYP4A11OPRM1SLC22A1SLC6A4 | |
| SCHEMBL13827636 | 0.85 | CYP4F2 (0.56) | CYP4F2CYP4A11MAPK1MEN1MAPT | |
| SCHEMBL12540731 | 0.84 | MAPK1 (0.46) | CYP4F2CYP4A11OPRM1SLC22A1SLC6A4 | |
| SCHEMBL5271625 | 0.81 | CYP4F2 (0.58) | CYP4F2CYP4A11MAPK1MEN1MAPT | |
| SCHEMBL22014300 | 0.77 | CYP2D6 (0.36) | CYP4F2CYP4A11OPRM1SLC22A1SLC6A4 | |
| SCHEMBL21963889 | 0.77 | PKM (0.47) | CYP4F2CYP4A11 | |
| SCHEMBL18597630 | 0.75 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL12578573 | 0.74 | USP2 (0.37) | CYP4F2CYP4A11OPRM1SLC22A1SLC6A4 | |
| SCHEMBL10151925 | 0.72 | CYP4F2 (0.41) | CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099885-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |