Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22013441 | 0.76 | MCL1 (0.35) | ALDH1A1 | |
| SCHEMBL380983 | 0.73 | GAA (0.48) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL1186304 | 0.70 | CYP2C19 (0.46) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL8264963 | 0.70 | CYP2C19 (0.50) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL867537 | 0.69 | CYP2C19 (0.53) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL9209379 | 0.67 | GAA (0.41) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL25025741 | 0.66 | ALDH1A1 (0.42) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL22254842 | 0.66 | ALDH1A1 (0.36) | KMT2AGAAMGAMSIMGAM2 | |
| SCHEMBL4113341 | 0.66 | OPRM1 (0.43) | KMT2AL3MBTL1GAAMGAMSI | |
| SCHEMBL2085077 | 0.66 | TSHR (0.44) | KMT2AL3MBTL1GAAMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3919490-A1 | FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR | Shanghai Ennovabio Pharmaceuticals Co., Ltd. (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020098720-A1 | FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR | 上海轶诺药业有限公司 | 2020-05-22 | — | — | WO | disclosed |