Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014790 | 0.87 | PAOX (0.41) | KEAP1SMN1; SMN2ALOX15ACE2SIGMAR1 | |
| SCHEMBL22015448 | 0.82 | ALOX15 (0.41) | ALOX15ACE2LOX | |
| SCHEMBL24209013 | 0.81 | SIGMAR1 (0.41) | KEAP1SMN1; SMN2ALOX15ACE2SIGMAR1 | |
| SCHEMBL22015437 | 0.81 | — | — | |
| SCHEMBL22779960 | 0.76 | ALOX15 (0.33) | ALOX15MEN1KMT2A | |
| SCHEMBL4564530 | 0.75 | PAOX (0.47) | SIGMAR1 | |
| SCHEMBL4342856 | 0.74 | KEAP1 (0.54) | KEAP1SMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL22014826 | 0.72 | CYP2D6 (0.62) | SIGMAR1CYP2D6MEN1KMT2A | |
| SCHEMBL28572354 | 0.69 | MEN1 (0.55) | KEAP1SMN1; SMN2ALOX15MEN1KMT2A | |
| SCHEMBL13485582 | 0.69 | PAOX (0.39) | SMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099886-A1 | LOX INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-05-22 | — | — | WO | disclosed |