Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014833 | 0.88 | RAB9A (0.40) | SMN1; SMN2LMNAKMT2AEIF4HMEN1 | |
| SCHEMBL22014827 | 0.88 | KMT2A (0.46) | SMN1; SMN2LMNAKMT2ARECQLMEN1 | |
| SCHEMBL22014820 | 0.83 | ACACB (0.40) | SMN1; SMN2MAPT | |
| SCHEMBL24209125 | 0.78 | SMN1; SMN2 (0.34) | SMN1; SMN2LMNAKMT2ARECQLEIF4H | |
| SCHEMBL22014835 | 0.78 | EIF4H (0.36) | SMN1; SMN2LMNAKMT2ARECQLEIF4H | |
| SCHEMBL22014834 | 0.76 | KMT2A (0.30) | KMT2A | |
| SCHEMBL22014822 | 0.73 | NPC1 (0.48) | LMNAKMT2ATSHRALDH1A1GAA | |
| SCHEMBL22804923 | 0.72 | AKR1C3 (0.44) | KMT2APOLBTSHRMAPTAKR1C3 | |
| SCHEMBL23701365 | 0.72 | AKR1C3 (0.44) | KMT2APOLBTSHRMAPTAKR1C3 | |
| SCHEMBL22015313 | 0.70 | ALDH1A1 (0.59) | SMN1; SMN2LMNAKMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099886-A1 | LOX INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-05-22 | — | — | WO | disclosed |