SCHEMBL22015325

SCHEMBL22015325

CCOc1ccc(N(c2ccc(C(C)(C)c3ccc(Br)cc3)cc2)c2ccc(C(C)(C)c3ccc(Br)cc3)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.45
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 5/20 0.41
MAPT P10636 3/20 0.41
TSHR P16473 3/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
TP53 P04637 2/20 0.41
HPGD P15428 2/20 0.41
HIF1A Q16665 2/20 0.41
CYP1A2 P05177 1/20 0.41
PPARG P37231 1/20 0.41
MAOB P27338 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
GAA P10253 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PSMB1 P20618 1/20 0.38
PSMB5 P28074 1/20 0.38
PSMB2 P49721 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8085396 0.88 NQO1 (0.58) NQO1ALDH1A1KDM4EMAPTTSHR
SCHEMBL22014956 0.83 KMT2A (0.43) ALDH1A1MAPTMEN1KMT2ATP53
SCHEMBL15703027 0.83 NQO1 (0.52) NQO1ALDH1A1KDM4EMAPTTSHR
SCHEMBL3035998 0.82 NQO1 (0.67) NQO1ALDH1A1MAPTTSHRMEN1
SCHEMBL18358 0.78 NQO1 (0.74) NQO1ALDH1A1KDM4EMAPTTSHR
SCHEMBL3239122 0.78 NQO1 (0.74) NQO1ALDH1A1KDM4EMAPTTSHR
SCHEMBL12701798 0.78 ALDH1A1 (0.48) ALDH1A1KDM4EMAPTTSHRMEN1
SCHEMBL13209791 0.77 NQO1 (0.58) NQO1ALDH1A1MAPTTSHRMEN1
SCHEMBL9804312 0.76 NQO1 (0.70) NQO1ALDH1A1KDM4EMAPTTSHR
SCHEMBL8962018 0.75 NQO1 (0.56) NQO1ALDH1A1KDM4EMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3024039-B1 ORGANIC SEMICONDUCTOR COMPOSITIONS SMARTKEM LTD (GB) 2020-05-20 EP disclosed