Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29198801 | 0.84 | KDM4E (0.49) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL32662010 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL19429469 | 0.79 | PKN1 (0.45) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL22993368 | 0.75 | CYP2C19 (0.38) | ALDH1A1KDM4EHSD17B10ALOX15MAPK1 | |
| SCHEMBL2747232 | 0.75 | KDM4E (0.59) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL4753189 | 0.75 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL435143 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL22035221 | 0.73 | KDM4E (0.49) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL22016196 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10NPSR1 | |
| SCHEMBL7175506 | 0.73 | GRIN2D (0.41) | ALDH1A1KDM4ENPSR1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2022-05-19 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ALDH1A1 476/4885HPGD 585/4885KDM4E 2522/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ALDH1A1 476/4885HPGD 585/4885KDM4E 2522/4885 |
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ALDH1A1 823/4885HPGD 3062/4885KDM4E 1442/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ALDH1A1 476/4885HPGD 585/4885KDM4E 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.