Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432799 | 0.83 | PTGS2 (0.63) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL22017083 | 0.82 | PTGS2 (0.45) | PTGS2HTR2AHTR2CHTR2BCA2 | |
| SCHEMBL1023208 | 0.82 | PTGS2 (0.41) | PTGS2HTR2AHTR2CHTR2BCA2 | |
| SCHEMBL13347320 | 0.80 | CA2 (0.41) | PTGS2HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL25460925 | 0.80 | HTR2A (0.61) | PTGS2HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL22031950 | 0.79 | PTGS2 (0.38) | PTGS2HTR2AHTR2CHTR2BCA2 | |
| SCHEMBL24312084 | 0.79 | PTGS2 (0.38) | PTGS2HTR2AHTR2CHTR2BCA2 | |
| SCHEMBL13754262 | 0.78 | PTGS2 (0.67) | PTGS2HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL19145278 | 0.78 | CA2 (0.61) | CA2POLBCALM1ALDH1A1L3MBTL1 | |
| SCHEMBL25460932 | 0.77 | HTR2A (0.57) | PTGS2HTR2AHTR2CHTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PTGS2 281/4885HTR2A 1691/4885HTR2C 804/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | PTGS2 281/4885HTR2A 1691/4885HTR2C 804/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | PTGS2 281/4885HTR2A 1691/4885HTR2C 804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.