Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 8/20 | 0.33 |
| ▸ | IDH2 | P48735 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22017351 | 1.00 | EPHX2 (0.36) | EPHX2IDH1IDH2DRD2DRD3 | |
| SCHEMBL22031954 | 1.00 | EPHX2 (0.36) | EPHX2IDH1IDH2DRD2DRD3 | |
| SCHEMBL104840 | 0.89 | MAPK8 (0.31) | DRD2DRD3 | |
| SCHEMBL25589867 | 0.87 | GAA (0.32) | — | |
| SCHEMBL104831 | 0.86 | EPHX2 (0.42) | EPHX2IDH1IDH2DRD2DRD3 | |
| SCHEMBL19687394 | 0.84 | IDH1 (0.38) | EPHX2IDH1IDH2 | |
| SCHEMBL23765209 | 0.83 | EPHX2 (0.31) | EPHX2 | |
| SCHEMBL25589542 | 0.83 | EPHX2 (0.31) | EPHX2 | |
| SCHEMBL9964559 | 0.80 | APLNR (0.31) | DRD2DRD3 | |
| SCHEMBL19687393 | 0.79 | EPHX2 (0.33) | EPHX2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11179383-B2 | Compounds for inhibition of α4β7 integrin | GILEAD SCIENCES, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200163953-A1 | Compounds for Inhibition of Alpha 4 Beta 7 Integrin | GILEAD SCIENCES, INC. | 2020-05-28 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200163953-A1 | Compounds for Inhibition of Alpha 4 Beta 7 Integrin | ITGB7, ITGB4, ITGA4 | EPHX2 2793/4885IDH1 4043/4885IDH2 4746/4885 |
| US-11179383-B2 | Compounds for inhibition of α4β7 integrin | ITGB7, ITGB4, ITGA4 | EPHX2 2865/4885IDH1 3807/4885IDH2 4717/4885 |
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | EPHX2 3262/4885IDH1 726/4885IDH2 1105/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | EPHX2 3262/4885IDH1 726/4885IDH2 1105/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | EPHX2 3262/4885IDH1 726/4885IDH2 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.