Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.33 |
| ▸ | ITGAV | P06756 | 6/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.32 |
| ▸ | RAF1 | P04049 | 4/20 | 0.32 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016634 | 1.00 | ATR (0.34) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22016631 | 1.00 | ATR (0.34) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22017546 | 0.97 | ITGB1 (0.34) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22016688 | 0.96 | RORC (0.34) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22035251 | 0.93 | ITGA4 (0.35) | ITGB1ITGA4ITGB7PIK3C3PIK3CA | |
| SCHEMBL22016606 | 0.91 | ITGB3 (0.36) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22016367 | 0.91 | TACR2 (0.33) | ATRITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL22016948 | 0.90 | ITGB1 (0.36) | ITGB1ITGB3ITGAVITGA5ITGB5 | |
| SCHEMBL22016703 | 0.90 | ITGB1 (0.36) | ITGB1ITGB3ITGAVITGA5ITGB5 | |
| SCHEMBL22016288 | 0.89 | ITGB1 (0.34) | ITGB1ITGB3ITGAVITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ATR 4499/4885ITGB1 3359/4885ITGB3 3939/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ATR 4499/4885ITGB1 3359/4885ITGB3 3939/4885 |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ATR 3978/4885ITGB1 2/4885ITGB3 13/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ATR 4499/4885ITGB1 3359/4885ITGB3 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.