Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126548 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL20153265 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13116989 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL21015372 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27442019 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL23808983 | 0.79 | RAB9A (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16565650 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12838847 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL19173962 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL235080 | 0.77 | KDM4E (0.65) | SMN1; SMN2ALDH1A1KDM4EKEAP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155563-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | SMN1; SMN2 1977/4885MEN1 3521/4885KMT2A 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.