Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15875058 | 0.76 | KMT2A (0.39) | HTTCDK5CDK5R1GAAMAPT | |
| SCHEMBL15875061 | 0.76 | KMT2A (0.39) | HTTCDK5CDK5R1GAAMAPT | |
| SCHEMBL22431375 | 0.74 | HTT (0.36) | HTTCDK5CDK5R1GAAMAPT | |
| SCHEMBL4637844 | 0.73 | GAA (0.42) | HTTCDK5CDK5R1GAAKMT2A | |
| SCHEMBL4637840 | 0.73 | GAA (0.42) | HTTCDK5CDK5R1GAAKMT2A | |
| SCHEMBL4637787 | 0.70 | GAA (0.39) | HTTCDK5CDK5R1GAAMAPT | |
| Acetic Acid SCHEMBL17395930 | 0.70 | KDM4E (0.39) | GAAMAPTPOLBNPC1MEN1 | |
| Acetic Acid SCHEMBL17395931 | 0.70 | KDM4E (0.39) | GAAMAPTPOLBNPC1MEN1 | |
| SCHEMBL28657657 | 0.70 | GRIN2D (0.60) | MAPTNPSR1NPC1KMT2AL3MBTL1 | |
| SCHEMBL15741494 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164123-B1 | NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES | INFLECTIS BIOSCIENCE (FR) | 2020-05-20 | — | — | EP | disclosed |