Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637909 | 0.85 | GAA (0.35) | GAAHTTCDK5CDK5R1MAPT | |
| SCHEMBL4637844 | 0.77 | GAA (0.42) | GAAHTTCDK5CDK5R1NFE2L2 | |
| SCHEMBL4637840 | 0.77 | GAA (0.42) | GAAHTTCDK5CDK5R1NFE2L2 | |
| SCHEMBL15741494 | 0.73 | — | — | |
| SCHEMBL28618300 | 0.72 | ALDH1A1 (0.50) | GAAMAPTNPSR1 | |
| SCHEMBL22017330 | 0.70 | HTT (0.41) | GAAHTTCDK5CDK5R1NFE2L2 | |
| SCHEMBL28657657 | 0.70 | GRIN2D (0.60) | MAPTNPSR1 | |
| SCHEMBL117895 | 0.70 | — | — | |
| SCHEMBL29954572 | 0.70 | — | — | |
| SCHEMBL3661431 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |