Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019206 | 0.87 | KDM4E (0.45) | KDM4ETDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL21957880 | 0.86 | KDM4E (0.44) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL31245546 | 0.86 | KDM4E (0.44) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL21957993 | 0.80 | KDM4E (0.42) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL31245513 | 0.80 | KDM4E (0.42) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL21958053 | 0.78 | KDM4E (0.41) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL30638431 | 0.76 | KDM4E (0.52) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL4608338 | 0.76 | KDM4E (0.52) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL22018757 | 0.75 | CHRM2 (0.41) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL3886138 | 0.74 | KDM4E (0.49) | KDM4ETDP1ALDH1A1L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | HBG1, HBG2, HBB | KDM4E 1774/4885TDP1 3819/4885ALDH1A1 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.