Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630876 | 0.84 | ALDH1A1 (0.48) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL30638431 | 0.83 | KDM4E (0.52) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL4608338 | 0.83 | KDM4E (0.52) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL123202 | 0.81 | KDM4E (0.57) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL9694340 | 0.81 | KDM4E (0.49) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL17746080 | 0.80 | KDM4E (0.55) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL2589045 | 0.78 | MAPT (0.61) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL30177224 | 0.78 | MAPT (0.61) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL258368 | 0.78 | KDM4E (0.53) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 | |
| Acetic Acid SCHEMBL16666942 | 0.78 | KDM4E (0.53) | KDM4ETDP1L3MBTL1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111400-A1 | PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS. | AstraZeneca AB (SE) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008085117-A1 | PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS. | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |