Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22018759 | 0.84 | SMN1; SMN2 (0.51) | ALDH1A1KDM4ENPSR1LMNAHTT | |
| SCHEMBL12141974 | 0.75 | SMN1; SMN2 (0.53) | ALDH1A1KDM4ENPSR1LMNAHTT | |
| SCHEMBL24135765 | 0.75 | ALDH1A1 (0.42) | HPGDALDH1A1KMT2APOLBCYP2C19 | |
| SCHEMBL18930367 | 0.74 | HPGD (0.49) | HPGDALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL24135783 | 0.73 | ALDH1A1 (0.41) | HPGDALDH1A1KMT2APOLBCYP2C19 | |
| SCHEMBL25719171 | 0.73 | ALDH1A1 (0.43) | HPGDALDH1A1KMT2ACYP2C19KDM4E | |
| SCHEMBL24135918 | 0.73 | KDM4E (0.41) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL24135856 | 0.72 | ALDH1A1 (0.40) | HPGDALDH1A1KMT2APOLBCYP2C19 | |
| SCHEMBL28304921 | 0.71 | ALDH1A1 (0.56) | HPGDALDH1A1KMT2APOLBCYP2C19 | |
| SCHEMBL16341717 | 0.71 | PARP1 (0.50) | HPGDALDH1A1KDM4EL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | HBG1, HBG2, HBB | HPGD 648/4885ALDH1A1 3168/4885KMT2A 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.