Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | FPR1 | P21462 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019978 | 0.84 | ACHE (0.54) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL24977965 | 0.81 | MAPK1 (0.49) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL22019781 | 0.81 | KDM4E (0.51) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL24977998 | 0.81 | KDM4E (0.46) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL22019724 | 0.80 | MAPK1 (0.54) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL28151465 | 0.75 | KDM4E (0.50) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL30657668 | 0.73 | HSD17B10 (0.58) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL12442826 | 0.72 | BCHE (0.65) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL13277920 | 0.72 | MAPT (0.47) | KDM4EMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL13169612 | 0.72 | BCHE (0.50) | KDM4EMAPTMAPK1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |