Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.54 |
| ▸ | BCHE | P06276 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.50 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.50 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.50 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.50 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.50 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.50 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.50 |
| ▸ | CACNG1 | Q06432 | 4/20 | 0.50 |
| ▸ | CACNB2 | Q08289 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019757 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL24474600 | 0.80 | ACHE (0.52) | ACHEBCHEKDM4EALDH1A1CACNB4 | |
| SCHEMBL22019781 | 0.79 | KDM4E (0.51) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL24977998 | 0.79 | KDM4E (0.46) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL24977965 | 0.79 | MAPK1 (0.49) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL22021439 | 0.78 | ACHE (0.54) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL30162420 | 0.78 | ACHE (0.54) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL30162655 | 0.78 | ACHE (0.54) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL22020129 | 0.78 | ACHE (0.54) | ACHEBCHEKDM4EALDH1A1ADORA2A | |
| SCHEMBL12884366 | 0.78 | KDM4E (0.67) | ACHEBCHEKDM4EALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230031406-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-02-02 | — | — | US | disclosed |
| US-20230031406-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-02-02 | — | — | US | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230031406-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NLRP1, NLRP3, NOD1 | ACHE 4177/4885BCHE 4143/4885KDM4E 4525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.