Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019961 | 0.83 | LMNA (0.49) | MAPK1LMNAHSD17B10FPR1KDM4E | |
| SCHEMBL30162655 | 0.83 | ACHE (0.54) | MAPK1LMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL22020129 | 0.83 | ACHE (0.54) | MAPK1LMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL24978509 | 0.82 | LMNA (0.48) | MAPK1LMNAHSD17B10FPR1KDM4E | |
| SCHEMBL22019757 | 0.80 | KDM4E (0.50) | MAPK1LMNAHSD17B10FPR1KDM4E | |
| SCHEMBL22019708 | 0.76 | SMN1; SMN2 (0.46) | MAPK1LMNAHSD17B10KDM4EMAPT | |
| SCHEMBL22020718 | 0.72 | SMN1; SMN2 (0.43) | MAPK1LMNAHSD17B10KDM4EMAPT | |
| SCHEMBL30162346 | 0.72 | TDP1 (0.39) | MAPK1LMNAKDM4EMAPTALDH1A1 | |
| SCHEMBL24977979 | 0.72 | MAPK1 (0.39) | MAPK1LMNAHSD17B10FPR1KDM4E | |
| SCHEMBL22020719 | 0.70 | SMN1; SMN2 (0.41) | MAPK1LMNAHSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |