Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.36 |
| ▸ | FEN1 | P39748 | 8/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1548065 | 0.81 | ALDH1A1 (0.40) | HPGDSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL16852675 | 0.80 | SMN1; SMN2 (0.36) | HPGDHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL11459269 | 0.76 | ALDH1A1 (0.61) | HPGDHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL16377391 | 0.67 | ALDH1A1 (0.46) | HPGDSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL1794606 | 0.67 | ALDH1A1 (0.46) | HPGDSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL11054324 | 0.66 | KMT2A (0.43) | HPGDHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL26663815 | 0.65 | MCL1 (0.54) | HPGDNPSR1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4972879 | 0.64 | NSD2 (0.41) | HPGDSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL21527775 | 0.64 | BRD4 (0.39) | HPGDSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL24429412 | 0.64 | CCR2 (0.50) | HPGDSMN1; SMN2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |