Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21963067 | 0.89 | GAA (0.46) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL25821017 | 0.85 | NLRP3 (0.50) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL25838016 | 0.81 | GAA (0.43) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22019806 | 0.79 | GAA (0.59) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22020723 | 0.78 | CYP1A2 (0.39) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL30162291 | 0.78 | CYP1A2 (0.39) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL21963248 | 0.76 | EEF2K (0.39) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22021099 | 0.74 | NLRP3 (0.48) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22021144 | 0.74 | NLRP3 (0.48) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22020326 | 0.73 | ACHE (0.50) | KDM4EMEN1KMT2AEEF2KACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-20160248025-A1 | Organic Electroluminescent Device | UDC IRELAND LTD (IE) | 2016-08-25 | — | — | US | disclosed |