Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25842158 | 0.86 | NLRP3 (0.46) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL25838016 | 0.85 | GAA (0.43) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL22020362 | 0.85 | GAA (0.43) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL25841799 | 0.81 | NLRP3 (0.43) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL22019806 | 0.80 | GAA (0.59) | CYP1A2GAANPSR1USP2MAPT | |
| SCHEMBL22021099 | 0.78 | NLRP3 (0.48) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL22021144 | 0.78 | NLRP3 (0.48) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL24978435 | 0.77 | NLRP3 (0.44) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL21963067 | 0.73 | GAA (0.46) | NLRP3CYP1A2GAANPSR1USP2 | |
| SCHEMBL21962951 | 0.72 | ACHE (0.52) | NLRP3CYP1A2EEF2KKDM4EACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |