Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.45 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24350922 | 0.81 | CHRM4 (0.51) | CHRM4CHRM2SLC6A2SLC6A4 | |
| SCHEMBL29300678 | 0.81 | OPRL1 (0.40) | CHRM4CHRM2OPRL1 | |
| SCHEMBL26265818 | 0.78 | CHRM4 (0.37) | CHRM4CHRM2OPRL1 | |
| SCHEMBL26269233 | 0.77 | MEN1 (0.42) | CHRM4GRM5CHRM2ALDH1A1 | |
| SCHEMBL23841511 | 0.77 | CHRM4 (0.40) | CHRM4CHRM2OPRL1SLC6A2SLC6A4 | |
| SCHEMBL21216421 | 0.77 | OPRL1 (0.39) | CHRM4CHRM2OPRL1SLC6A2SLC6A4 | |
| SCHEMBL16880332 | 0.76 | CHRM4 (0.47) | CHRM4CHRM2ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL365001 | 0.75 | HTR1A (0.39) | CHRM4CHRM2OPRL1SLC6A2SLC6A4 | |
| SCHEMBL17029329 | 0.74 | OPRL1 (0.41) | CHRM4CHRM2ALDH1A1OPRL1KDM4E | |
| SCHEMBL367660 | 0.74 | ADRA1A (0.42) | CHRM4CHRM2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | PFIZER INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | DPYD, PDXK, TYMP | CHRM4 4090/4885GRM5 3264/4885CHRM2 4076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.