SCHEMBL22029344

SCHEMBL22029344

NS(=O)(=O)c1ccc(C#Cc2ccc(O)cc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 12/20 0.75
CA1 P00915 11/20 0.75
CA12 O43570 9/20 0.75
CA9 Q16790 9/20 0.75
CA7 P43166 1/20 0.60
ALOX5 P09917 1/20 0.57
PTPN6 P29350 1/20 0.56
CA4 P22748 1/20 0.55
CA14 Q9ULX7 1/20 0.55
APP P05067 1/20 0.54
PTGS2 P35354 2/20 0.50
PTGS1 P23219 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL283769 0.87 CA2 (1.00) CA2CA1CA12CA9CA7
SCHEMBL11023570 0.84 CA2 (0.95) CA2CA1CA12CA9CA7
Hydrochloric Acid SCHEMBL29969444 0.84 CA2 (0.95) CA2CA1CA12CA9CA7
SCHEMBL22243575 0.78 CA12 (0.63) CA2CA1CA12CA9CA7
SCHEMBL5867219 0.77 CA2 (0.68) CA2CA1CA12CA9CA7
SCHEMBL673609 0.76 APP (0.74) CA2CA1CA12CA9CA4
SCHEMBL14400750 0.76 APP (0.74) CA2CA1CA12CA9CA4
SCHEMBL5067825 0.76 CA12 (0.58) CA2CA1CA12CA9APP
SCHEMBL5527294 0.75 CA2 (0.75) CA2CA1CA12CA9CA7
SCHEMBL22029399 0.75 CA2 (0.75) CA2CA1CA12CA9CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893934-B1 INSULIN CONJUGATES SANOFI SA (FR) 2025-09-10 EP disclosed
US-20250206798-A1 INSULIN CONJUGATES SANOFI SA (FR) 2025-06-26 US disclosed
US-12195510-B2 Insulin conjugates SANOFI (FR) 2025-01-14 US disclosed
US-20220048968-A1 INSULIN CONJUGATES SANOFI (FR) 2022-02-17 US disclosed
US-20220048968-A1 INSULIN CONJUGATES SANOFI (FR) 2022-02-17 US disclosed
EP-3894391-A1 PEPTIDE BINDER SANOFI (FR) 2021-10-20 EP disclosed
EP-3893934-A1 INSULIN CONJUGATES SANOFI (FR) 2021-10-20 EP disclosed
CN-113423691-A Peptide binding agents 赛诺菲 2021-09-21 CN disclosed
CN-113395982-A Insulin conjugates 赛诺菲 2021-09-14 CN disclosed
WO-2020120463-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-18 WO disclosed
WO-2020120479-A1 PEPTIDE BINDER SANOFI (FR) 2020-06-18 WO disclosed
WO-2020120479-A1 PEPTIDE BINDER SANOFI (FR) 2020-06-18 WO disclosed
WO-2020120463-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-18 WO disclosed
US-20200181223-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-11 US disclosed
US-20200181223-A1 INSULIN CONJUGATES SANOFI (FR) 2020-06-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200181223-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R CA2 1521/4885CA1 1162/4885CA12 453/4885
US-20220048968-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R CA2 1521/4885CA1 1162/4885CA12 453/4885
US-12195510-B2 Insulin conjugates IAPP, INSR, IGF1R CA2 1521/4885CA1 1162/4885CA12 453/4885
US-20250206798-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R CA2 1521/4885CA1 1162/4885CA12 453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.