Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22811914 | 0.86 | RET (0.46) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL18713100 | 0.86 | ALDH1A1 (0.50) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL20070594 | 0.86 | CPS1 (0.48) | RETTAS1R3TAS1R1ALDH1A1MEN1 | |
| SCHEMBL20152357 | 0.83 | RET (0.46) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL18389841 | 0.83 | TAS1R3 (0.46) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL20071172 | 0.83 | TAS1R3 (0.46) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL18389839 | 0.81 | TAS1R3 (0.44) | RETTAS1R3TAS1R1HSD11B1ALDH1A1 | |
| SCHEMBL10244040 | 0.73 | DRD2 (0.44) | TAS1R3TAS1R1ALDH1A1TP53KMT2A | |
| SCHEMBL17350650 | 0.73 | DRD2 (0.44) | TAS1R3TAS1R1ALDH1A1TP53KMT2A | |
| SCHEMBL18713099 | 0.72 | HTT (0.51) | RETTAS1R3TAS1R1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |