Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 18/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | TSPO | P30536 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172463 | 0.85 | P2RY14 (0.65) | P2RY14OPRD1KCNH2TMEM97TSPO | |
| SCHEMBL357679 | 0.83 | NOTUM (0.44) | P2RY14NOTUM | |
| SCHEMBL2204284 | 0.79 | KCNJ1 (0.39) | P2RY14OPRD1 | |
| SCHEMBL2203428 | 0.78 | P2RX7 (0.54) | P2RY14 | |
| SCHEMBL28475663 | 0.77 | P2RY14 (0.51) | P2RY14OPRD1KCNH2TMEM97TSPO | |
| SCHEMBL4321362 | 0.75 | SMN1; SMN2 (0.44) | P2RY14OPRD1KCNH2NOTUM | |
| SCHEMBL4324303 | 0.74 | SMN1; SMN2 (0.53) | P2RY14NOTUM | |
| SCHEMBL29994366 | 0.74 | MRGPRX4 (0.57) | — | |
| SCHEMBL4320066 | 0.73 | P2RY14 (0.47) | P2RY14OPRD1KCNH2TMEM97TSPO | |
| SCHEMBL15569573 | 0.73 | NOTUM (0.53) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-B1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | disclosed |
| US-7981914-B2 | Tetrazole-substituted aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090093523-A1 | Tetrazole-substituted aryl amide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093523-A1 | Tetrazole-substituted aryl amide derivatives and uses thereof | AR, NAT1, TBXA2R | P2RY14 3075/4885OPRD1 1006/4885KCNH2 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.