Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | TSPO | P30536 | 1/20 | 0.55 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10689750 | 0.85 | ADORA2A (0.59) | ADORA1ADORA3ADORA2AP2RX3P2RX4 | |
| SCHEMBL22983997 | 0.85 | P2RX3 (0.59) | P2RX3P2RX4P2RX2PRKAB2PRKAG1 | |
| SCHEMBL5982554 | 0.81 | PRMT6 (0.62) | P2RX3P2RX4P2RX2PRKAB2PRKAG1 | |
| SCHEMBL9002261 | 0.81 | P2RX3 (0.60) | P2RX3P2RX4P2RX2PRKAB2PRKAG1 | |
| SCHEMBL13169185 | 0.81 | P2RX3 (0.75) | P2RX3P2RX4P2RX2LMNAMEN1 | |
| SCHEMBL9002254 | 0.81 | P2RX3 (0.60) | P2RX3P2RX4P2RX2PRKAB2PRKAG1 | |
| SCHEMBL9141432 | 0.81 | P2RX3 (0.60) | P2RX3P2RX4P2RX2PRKAB2PRKAG1 | |
| SCHEMBL12352429 | 0.81 | P2RX3 (0.75) | P2RX3P2RX4P2RX2LMNAMEN1 | |
| SCHEMBL9189337 | 0.81 | P2RX3 (0.75) | P2RX3P2RX4P2RX2LMNAMEN1 | |
| SCHEMBL12243789 | 0.81 | P2RX3 (0.75) | P2RX3P2RX4P2RX2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12378248-B2 | A1 adenosine receptor agonists and methods of use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2025-08-05 | — | — | US | disclosed |
| US-20220024926-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-01-27 | — | — | US | disclosed |
| WO-2020118139-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12378248-B2 | A1 adenosine receptor agonists and methods of use thereof | ADORA1, ADORA2A, ADORA2B | ADORA1 1/4885ADORA3 4/4885ADORA2A 2/4885 |
| US-20220024926-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | ADORA1, ADORA2A, ADORA2B | ADORA1 1/4885ADORA3 4/4885ADORA2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.