Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588045 | 0.78 | HSD11B1 (1.00) | HSD11B1CHRM1MAPK1LMNAHTT | |
| SCHEMBL4777481 | 0.76 | L3MBTL1 (0.61) | LMNAHTTALDH1A1CHRM4 | |
| SCHEMBL22605797 | 0.76 | HSD11B1 (0.65) | HSD11B1CHRM1MAPK1LMNAHTT | |
| SCHEMBL1833332 | 0.76 | HSD11B1 (0.68) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| SCHEMBL21045924 | 0.75 | HSD11B1 (0.56) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| SCHEMBL29557148 | 0.75 | HSD11B1 (0.56) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| SCHEMBL29872667 | 0.75 | HSD11B1 (0.67) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| SCHEMBL1760919 | 0.75 | HSD11B1 (0.67) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| SCHEMBL5774178 | 0.75 | HSD11B1 (0.67) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL3106327 | 0.75 | HSD11B1 (0.67) | HSD11B1CHRM1MAPK1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | claimed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-7977374-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-07-12 | — | — | US | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | HSD11B1 90/4885CHRM1 4734/4885MAPK1 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.