SCHEMBL4777481

SCHEMBL4777481

O=C(c1ccc(C(=O)C(F)(F)F)s1)N1CCC(n2nnc3ccccc32)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.61
MEN1 O00255 1/20 0.61
NPC1 O15118 1/20 0.61
RAB9A P51151 1/20 0.61
KMT2A Q03164 1/20 0.61
ALDH1A1 P00352 6/20 0.57
USP2 O75604 2/20 0.54
HDAC6 Q9UBN7 4/20 0.53
HDAC1 Q13547 3/20 0.53
HDAC3 O15379 2/20 0.53
CYP2C9 P11712 2/20 0.53
LMNA P02545 2/20 0.50
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CHRM4 P08173 1/20 0.46
KDM4E B2RXH2 1/20 0.46
MAPT P10636 1/20 0.46
TNKS O95271 1/20 0.45
PARP1 P09874 1/20 0.45
PARP2 Q9UGN5 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2203386 0.76 HSD11B1 (0.67) ALDH1A1LMNAHTTCHRM4
SCHEMBL5751254 0.76 ALDH1A1 (0.70) L3MBTL1MEN1NPC1RAB9AKMT2A
SCHEMBL6431101 0.74 MEN1 (0.57) L3MBTL1MEN1NPC1RAB9AKMT2A
SCHEMBL2204285 0.73 HDAC6 (0.55) L3MBTL1ALDH1A1HDAC6HDAC1HDAC3
SCHEMBL17707579 0.72 HDAC6 (0.56) L3MBTL1RAB9AALDH1A1HDAC6HDAC1
SCHEMBL17707597 0.72 L3MBTL3 (0.61) L3MBTL1MEN1KMT2AALDH1A1HDAC6
SCHEMBL2202147 0.72 ALDH1A1 (0.60) MEN1KMT2AALDH1A1HDAC6HDAC1
SCHEMBL2202464 0.71 CYP2C9 (0.62) MEN1KMT2AHDAC6HDAC1HDAC3
Trifluoroacetic Acid SCHEMBL6431095 0.71 KMT2A (0.52) L3MBTL1MEN1NPC1RAB9AKMT2A
SCHEMBL4405502 0.70 ALDH1A1 (0.62) L3MBTL1MEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926721-B1 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS MSD ITALIA SRL (IT) 2016-05-04 EP claimed
EP-1926721-B1 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS MSD ITALIA SRL (IT) 2016-05-04 EP disclosed
EP-1926721-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) 2008-06-04 EP disclosed
WO-2007029035-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-03-15 WO disclosed