Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496559 | 0.86 | FAAH (0.57) | MMP2MMP13MMP14MAPTCYP1A2 | |
| SCHEMBL22578393 | 0.85 | TP53 (0.54) | MMP2MMP13MMP14MAPTFAAH | |
| SCHEMBL2203114 | 0.85 | RPA1 (0.51) | MAPTGRM5RPA1ALDH1A1PLA2G10 | |
| SCHEMBL4296485 | 0.84 | GRM5 (0.55) | MMP2MMP13MMP14FAAHGRM5 | |
| SCHEMBL4504419 | 0.83 | PLA2G10 (0.55) | FAAHGRM5RPA1KDM4EALDH1A1 | |
| SCHEMBL3972438 | 0.81 | MMP2 (0.44) | MMP2MMP13MMP14MAPTCYP1A2 | |
| SCHEMBL3712001 | 0.80 | MALT1 (0.51) | MAPTRECQLCYP1A2GAAFAAH | |
| SCHEMBL12278777 | 0.78 | NR4A2 (0.49) | MMP2MMP13MMP14MAPTALDH1A1 | |
| SCHEMBL25221707 | 0.77 | NOTUM (0.56) | MMP2MMP13MMP14RPA1KDM4E | |
| SCHEMBL30982319 | 0.77 | NOTUM (0.56) | MMP2MMP13MMP14RPA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| CN-111263759-B | Isoxazole derivative and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-3730491-B1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2022-07-20 | — | — | EP | disclosed |
| US-20200339558-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BiOTECH BIGPHARMACEUTICAL CO., LTD. (CN) | 2020-10-29 | — | — | US | disclosed |
| US-20200339558-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BiOTECH BIGPHARMACEUTICAL CO., LTD. (CN) | 2020-10-29 | — | — | US | disclosed |
| EP-3730491-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-10-28 | — | — | EP | disclosed |
| EP-3730491-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-10-28 | — | — | EP | disclosed |
| CN-111263759-A | Isoxazole derivative and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339558-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | CYP4A11, CYP4F11, SLC10A1 | MMP2 4423/4885MMP13 3976/4885MMP14 2830/4885 |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | MMP2 247/4885MMP13 520/4885MMP14 862/4885 |
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | CYP4A11, CYP4F11, SLC10A1 | MMP2 4423/4885MMP13 3976/4885MMP14 2830/4885 |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | MMP2 3554/4885MMP13 3612/4885MMP14 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.