Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPAST | Q9UBP0 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 5/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889437 | 0.83 | PLK4 (0.66) | PLK4PAK4NTRK1AURKA | |
| SCHEMBL4073913 | 0.80 | SPAST (0.58) | SPASTNTRK1IGF1RAURKA | |
| SCHEMBL22034758 | 0.74 | SPAST (0.74) | SPASTPLK4PAK4IGF1R | |
| SCHEMBL22034761 | 0.74 | SPAST (0.74) | SPASTPLK4PAK4IGF1R | |
| SCHEMBL28411572 | 0.74 | PLK4 (0.41) | SPASTPLK4PAK4TGFBR1TTBK1 | |
| SCHEMBL30250297 | 0.74 | PLK4 (0.41) | SPASTPLK4PAK4TGFBR1TTBK1 | |
| SCHEMBL2120951 | 0.74 | NTRK1 (0.58) | SPASTPLK4PAK4NTRK1IGF1R | |
| SCHEMBL14287415 | 0.73 | XDH (0.45) | TTBK1TTBK2 | |
| SCHEMBL2120929 | 0.72 | IGF1R (0.64) | PLK4PAK4NTRK1IGF1R | |
| SCHEMBL17397443 | 0.72 | IGF1R (0.67) | PLK4PAK4NTRK1IGF1RPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020118183-A1 | 2,4-DIAMINOPYRIMIDINE BICYCLES FOR TREATING CANCER | KAPOOR TARUN M (US) | 2020-06-11 | — | — | WO | disclosed |