Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | NPY2R | P49146 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11856247 | 0.90 | ADRB1 (0.76) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL10739631 | 0.90 | ADRB1 (0.76) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL28407475 | 0.87 | ADRB1 (0.73) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| (S)-Metoprolol SCHEMBL121589 | 0.86 | ADRB1 (1.00) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| Metoprolol SCHEMBL1561123 | 0.86 | ADRB1 (1.00) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| Metoprolol SCHEMBL4093 | 0.86 | ADRB1 (1.00) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| (R)-Metoprolol SCHEMBL40918 | 0.86 | ADRB1 (1.00) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL3462992 | 0.86 | ADRB2 (0.75) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| (S)-Metoprolol SCHEMBL2638035 | 0.85 | ADRB1 (0.97) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| (S)-Metoprolol SCHEMBL6728301 | 0.85 | ADRB1 (0.97) | ADRB1ADRB2CYP2D6NR3C1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108680676-B | Method for quantitatively detecting beta-receptor blocker medicines in dairy products | 中国检验检疫科学研究院 | 2021-08-13 | — | — | CN | claimed |
| CN-108680676-B | Method for quantitatively detecting beta-receptor blocker medicines in dairy products | 中国检验检疫科学研究院 | 2021-08-13 | — | — | CN | disclosed |
| US-20140088189-A1 | METHODS FOR REDUCING THE RISK OF AN ADVERSE DRONEDARONE / BETA-BLOCKERS INTERACTION IN A PATIENT SUFFERING FROM ATRIAL FIBRILATION | SANOFI (FR) | 2014-03-27 | — | — | US | disclosed |
| US-8602215-B2 | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation | SANOFI (FR) | 2013-12-10 | — | — | US | disclosed |
| US-20120000806-A1 | METHODS FOR REDUCING THE RISK OF AN ADVERSE DRONEDARONE / BETA-BLOCKERS INTERACTION IN A PATIENT SUFFERING FROM ATRIAL FIBRILATION | SANOFI (FR) | 2012-01-05 | — | — | US | disclosed |
| WO-2005038049-A2 | SYSTEM AND METHOD FOR OPTIMIZING DRUG THERAPY | HEINRICH GUENTHER (DE) | 2005-04-28 | — | — | WO | disclosed |