Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21676102 | 0.86 | TDP1 (0.44) | ERN1TDP1NFE2L2CDK4CCND1 | |
| SCHEMBL16599459 | 0.86 | TDP1 (0.44) | ERN1TDP1NFE2L2CDK4CCND1 | |
| SCHEMBL31182057 | 0.82 | NFE2L2 (0.57) | ERN1NFE2L2CDK4CCND1ALDH1A1 | |
| SCHEMBL28908861 | 0.82 | TDP1 (0.47) | ERN1TDP1CDK4CCND1ALDH1A1 | |
| SCHEMBL706361 | 0.82 | NFE2L2 (0.57) | ERN1NFE2L2CDK4CCND1ALDH1A1 | |
| SCHEMBL706360 | 0.82 | NFE2L2 (0.57) | ERN1NFE2L2CDK4CCND1ALDH1A1 | |
| SCHEMBL28908860 | 0.82 | TDP1 (0.47) | ERN1TDP1CDK4CCND1ALDH1A1 | |
| SCHEMBL42333 | 0.79 | ERN1 (0.59) | ERN1TDP1NFE2L2LMNAXDH | |
| SCHEMBL29958016 | 0.79 | ERN1 (0.59) | ERN1TDP1NFE2L2LMNAXDH | |
| SCHEMBL21676110 | 0.78 | SMN1; SMN2 (0.42) | ERN1NFE2L2CDK4CCND1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165205-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165205-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | MAP3K19, MAP3K20, MAP3K1 | ERN1 424/4885TDP1 2148/4885NFE2L2 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.