SCHEMBL42333

SCHEMBL42333

O=Cc1cc(Cl)ccc1F

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 9/20 0.59
TDP1 Q9NUW8 2/20 0.58
HSD17B10 Q99714 1/20 0.42
PTPN1 P18031 1/20 0.42
NFE2L2 Q16236 1/20 0.39
XDH P47989 1/20 0.39
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
THRB P10828 1/20 0.36
BLM P54132 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29958016 1.00 ERN1 (0.59) ERN1TDP1HSD17B10PTPN1NFE2L2
SCHEMBL155661 0.84 TDP1 (0.61) ERN1TDP1HSD17B10PTPN1LMNA
SCHEMBL4357334 0.80 TDP1 (0.70) ERN1TDP1HSD17B10PTPN1XDH
SCHEMBL14774600 0.80 TDP1 (0.52) ERN1TDP1PTPN1NFE2L2MEN1
SCHEMBL14774601 0.80 TDP1 (0.52) ERN1TDP1PTPN1NFE2L2MEN1
SCHEMBL22039183 0.79 ERN1 (0.42) ERN1TDP1HSD17B10NFE2L2XDH
SCHEMBL5175967 0.78 SOS1 (0.44) ERN1TDP1HSD17B10NFE2L2MEN1
SCHEMBL65723 0.78 ERN1 (0.56) ERN1PTPN1NFE2L2
Water SCHEMBL28578537 0.78 TDP1 (0.67) ERN1TDP1HSD17B10PTPN1XDH
SCHEMBL42560 0.78 TDP1 (0.67) ERN1TDP1HSD17B10PTPN1XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 564 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114380815-A Phytoalexin derivative and preparation method and application thereof 河北工业大学 2022-04-22 CN claimed
CN-113735842-A 1,2, 4-triazole Schiff base thioether derivatives, and preparation method and application thereof 河北农业大学 2021-12-03 CN claimed
CN-105294562-B A kind of preparation method of the chloro- 5- oxo -2,3,4,5- tetrahydro -1H-1- benzazepine of 7- 长春吉大天元化学技术股份有限公司 2019-04-16 CN claimed
US-10017684-B2 Method and compositions for hydraulic fracturing and for tracing formation water SPECTRUM TRACER SERVICES, LLC (US) 2018-07-10 US claimed
US-20170306217-A1 METHOD AND COMPOSITIONS FOR HYDRAULIC FRACTURING AND FOR TRACING FORMATION WATER NCS Multistage, LLC 2017-10-26 US claimed
CN-105294562-A Preparation method of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzo[b]azepine CHANGCHUN DISCOVERY SCIENCES LTD 2016-02-03 CN claimed
WO-2026107418-A1 N-(4-(1H-BENZO[D[IMIDAZOL-6-YL)-PYRIDIN-2-YL)BENZAMIDE DERIVATIVES AS CAMK2 INHIBITORS FOR THE TREATMENT OF HEART FAILURE BRISTOL-MYERS SQUIBB COMPANY (US) 2026-05-21 WO disclosed
WO-2026107424-A1 N-(4-(IMIDAZO[4,5-B]PYRIDIN-5-YL)-2-PYRIDYL)BENZAMIDE DERIVATIVES AS CAMK2 INHIBITORS FOR THE TREATMENT OF HEART FAILURE BRISTOL-MYERS SQUIBB COMPANY (US) 2026-05-21 WO disclosed
US-20260116857-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS PARDES BIOSCIENCES INC (US) 2026-04-30 US disclosed
EP-3558298-B1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME LLC (US) 2026-03-11 EP disclosed
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
US-12404274-B2 Macrocycles as factor xia inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2025-09-02 US disclosed
EP-4605409-A2 CYCLIN INHIBITORS Circle Pharma, Inc. (US) 2025-08-27 EP disclosed
US-5015757-A Fungicides BAYER AKTIENGESELLSCHAFT (DE) 1991-05-14 US disclosed
US-4977182-A Fungicidal 3-cyano-4-phenyl-pyrroles BAYER AKTIENGESELLSCHAFT (DE) 1990-12-11 US disclosed
US-4960789-A FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-10-02 US disclosed
EP-0339417-A1 3-Cyano-4-phenyl-pyrroles BAYER AG (DE) 1989-11-02 EP disclosed
EP-0318704-A2 3-Cyano-4-phenyl-pyrrole derivatives BAYER AG (DE) 1989-06-07 EP disclosed
CN-1030236-A NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS WELLCOME FOUND (GB) 1989-01-11 CN disclosed
EP-0294229-A2 Novel heterocyclic pesticidal compounds THE WELLCOME FOUNDATION LIMITED (GB) 1988-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 ERN1 1140/4885TDP1 722/4885HSD17B10 134/4885
US-12404274-B2 Macrocycles as factor xia inhibitors TFPI, TFPI2, F11 ERN1 1605/4885TDP1 2393/4885HSD17B10 1803/4885
US-20260116857-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS CTRC, CTRL, CTSL ERN1 607/4885TDP1 2135/4885HSD17B10 856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.