Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22041587 | 0.85 | LMNA (0.43) | LMNAMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29659631 | 0.85 | LMNA (0.43) | LMNAMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22966242 | 0.81 | DHODH (0.36) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23086251 | 0.81 | ALDH1A1 (0.41) | LMNAMAPTALDH1A1KDM4EPOLB | |
| SCHEMBL22966213 | 0.80 | F2 (0.36) | LMNAMAPTALDH1A1NPSR1NPC1 | |
| SCHEMBL22966285 | 0.80 | SCN5A (0.37) | MAPTTP53EGLN1 | |
| SCHEMBL22966184 | 0.78 | MAPT (0.39) | LMNAMAPTALDH1A1KDM4EPOLB | |
| SCHEMBL22966183 | 0.78 | EGFR (0.41) | LMNAMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22966234 | 0.78 | EGFR (0.38) | LMNAMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22966210 | 0.78 | SLC6A2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111566088-B | Quinoline derivative and preparation method and application thereof | 东莞市东阳光农药研发有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-111566088-A | Quinoline derivative and preparation method and application thereof | 东莞市东阳光农药研发有限公司 | 2020-08-21 | — | — | CN | disclosed |
| WO-2020113554-A1 | QUINOLINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | 东莞市东阳光农药研发有限公司 | 2020-06-11 | — | — | WO | disclosed |