Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 10/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22041622 | 0.83 | GPR35 (0.51) | GPR35HPGDALDH1A1KDM4EGLA | |
| SCHEMBL22041628 | 0.81 | GPR35 (0.47) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL22041598 | 0.78 | GPR35 (0.55) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL22041638 | 0.77 | GPR35 (0.52) | GPR35HPGDALDH1A1KDM4EGLA | |
| SCHEMBL22041606 | 0.70 | GPR35 (0.71) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL22041599 | 0.69 | GPR35 (0.52) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL18306420 | 0.66 | MAOA (0.71) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL11532310 | 0.65 | MAPT (0.48) | GPR35HPGDUSP2POLBALOX15 | |
| SCHEMBL22041603 | 0.65 | GPR35 (0.53) | GPR35MAOACA12CA1CA2 | |
| SCHEMBL22041589 | 0.65 | GPR35 (0.50) | GPR35HPGDUSP2POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285790-A | 3-carboxycoumarin derivative capable of serving as GPR35 agonist, preparation method and application | 泰州医药城国科化物生物医药科技有限公司 | 2020-06-16 | — | — | CN | claimed |
| WO-2020114290-A1 | 3-CARBOXYL COUMARIN DERIVATIVE CAPABLE OF BEING USED AS A GPR35 AGONIST, PREPARATION METHOD, AND APPLICATION | 泰州医药城国科化物生物医药科技有限公司 | 2020-06-11 | — | — | WO | claimed |
| CN-111285790-A | 3-carboxycoumarin derivative capable of serving as GPR35 agonist, preparation method and application | 泰州医药城国科化物生物医药科技有限公司 | 2020-06-16 | — | — | CN | disclosed |
| WO-2020114290-A1 | 3-CARBOXYL COUMARIN DERIVATIVE CAPABLE OF BEING USED AS A GPR35 AGONIST, PREPARATION METHOD, AND APPLICATION | 泰州医药城国科化物生物医药科技有限公司 | 2020-06-11 | — | — | WO | disclosed |