Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.67 |
| ▸ | PGR | P06401 | 7/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | IL6 | P05231 | 1/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.67 |
| ▸ | GLUL | P15104 | 1/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945986 | 1.00 | NR3C1 (0.67) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL11016342 | 0.93 | NR3C2 (0.72) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL6857093 | 0.93 | NR3C2 (0.72) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL6857090 | 0.93 | NR3C2 (0.72) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL871871 | 0.92 | HIF1A (0.70) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| Prednival SCHEMBL11585728 | 0.92 | HIF1A (0.73) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| Prednival SCHEMBL25388 | 0.92 | HIF1A (0.73) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL1945621 | 0.92 | NR3C1 (0.67) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| SCHEMBL1945625 | 0.92 | NR3C1 (0.67) | NR3C1PGRNR3C2HIF1AHSD17B10 | |
| Prednival SCHEMBL25387 | 0.92 | HIF1A (0.73) | NR3C1PGRNR3C2HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020116636-A1 | IMMUNOSUPPRESSANT | 小野薬品工業株式会社 | 2020-06-11 | — | — | WO | disclosed |