Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA3 | P07451 | 6/20 | 0.39 |
| ▸ | CA6 | P23280 | 6/20 | 0.39 |
| ▸ | CA7 | P43166 | 6/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.39 |
| ▸ | CA5A | P35218 | 4/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22043870 | 0.89 | ALOX15 (0.52) | ALOX15MEN1KMT2AL3MBTL1CNR2 | |
| SCHEMBL22043521 | 0.88 | ALOX15 (0.48) | ALOX15MEN1KMT2AL3MBTL1CNR2 | |
| SCHEMBL22043546 | 0.82 | ALOX15 (0.67) | ALOX15MEN1KMT2AALDH1A1CNR2 | |
| SCHEMBL22043531 | 0.82 | ALOX15 (0.67) | ALOX15MEN1KMT2AALDH1A1CNR2 | |
| SCHEMBL22043691 | 0.81 | ALOX15 (0.65) | ALOX15CA1CA2CA12MEN1 | |
| SCHEMBL23873653 | 0.75 | ALOX15 (0.50) | ALOX15MEN1KMT2ACNR2EPHX2 | |
| SCHEMBL22043538 | 0.71 | CNR2 (0.37) | ALOX15L3MBTL1CNR2EPHX2EPHX1 | |
| SCHEMBL27040186 | 0.71 | MEN1 (0.41) | ALOX15CA1CA2CA3CA6 | |
| SCHEMBL22043539 | 0.69 | ALOX15 (0.70) | ALOX15MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL23683898 | 0.69 | HCAR3 (0.42) | MEN1KMT2ACNR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240156790-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2024-05-16 | — | — | US | disclosed |
| US-20210299107-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2021-09-30 | — | — | US | disclosed |
| WO-2020113028-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240156790-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, SLC7A11 | ALOX15 286/4885CA1 395/4885CA2 1068/4885 |
| US-20210299107-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, SLC7A11 | ALOX15 286/4885CA1 395/4885CA2 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.