⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27352555 | 0.80 | ALDH1A1 (0.33) | — | |
| SCHEMBL12589081 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL29838618 | 0.74 | NUDT1 (0.36) | — | |
| SCHEMBL14423849 | 0.72 | — | — | |
| SCHEMBL23892010 | 0.70 | ALDH1A1 (0.31) | — | |
| SCHEMBL21984572 | 0.69 | TSHR (0.33) | — | |
| SCHEMBL22859889 | 0.68 | — | — | |
| SCHEMBL9300187 | 0.68 | — | — | |
| SCHEMBL12784557 | 0.67 | — | — | |
| SCHEMBL14926931 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |