Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344607 | 0.84 | ALDH1A1 (0.37) | THRBPOLBTP53MAPT | |
| SCHEMBL19980218 | 0.79 | CAPN1 (0.37) | POLBCTSL | |
| SCHEMBL19980277 | 0.74 | POLB (0.46) | THRBPOLBTP53HCAR2SNCA | |
| SCHEMBL19980297 | 0.73 | CAPN1 (0.33) | — | |
| SCHEMBL19037430 | 0.72 | CAPN1 (0.36) | CTSL | |
| SCHEMBL19659195 | 0.71 | HDAC3 (0.35) | THRBPOLBLMNAMAPTFPR1 | |
| SCHEMBL22710309 | 0.69 | POLB (0.33) | THRBPOLBTP53LMNAMAPT | |
| SCHEMBL22888658 | 0.68 | PDE2A (0.37) | POLBMAPT | |
| SCHEMBL22888034 | 0.68 | PDE2A (0.30) | — | |
| SCHEMBL15964735 | 0.68 | HCAR2 (0.53) | THRBPOLBTP53HCAR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |