Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048482 | 0.84 | THRB (0.35) | POLBTHRBMAPTTP53 | |
| SCHEMBL22048479 | 0.79 | POLB (0.41) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL22710309 | 0.77 | POLB (0.33) | ALDH1A1SMN1; SMN2POLBTHRBMEN1 | |
| SCHEMBL19980277 | 0.74 | POLB (0.46) | POLBTHRBMAPTTP53 | |
| SCHEMBL19980451 | 0.69 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL15964735 | 0.68 | HCAR2 (0.53) | POLBTHRBMAPTTP53 | |
| SCHEMBL15964837 | 0.67 | HCAR2 (0.46) | POLBTP53 | |
| SCHEMBL22888233 | 0.67 | HDAC6 (0.36) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL20344523 | 0.67 | HPGD (0.36) | ALDH1A1POLBMEN1KMT2AMAPT | |
| SCHEMBL19980218 | 0.67 | CAPN1 (0.37) | ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |