Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964735 | 0.85 | HCAR2 (0.53) | POLBTP53HCAR2THRBLMNA | |
| SCHEMBL15964837 | 0.83 | HCAR2 (0.46) | POLBTP53HCAR2IDH1NR3C2 | |
| SCHEMBL18377480 | 0.83 | BRD4 (0.48) | — | |
| SCHEMBL15957045 | 0.83 | PTGES (0.53) | POLBTP53HCAR2LMNAMAPT | |
| SCHEMBL30091541 | 0.83 | PTGES (0.53) | POLBTP53HCAR2LMNAMAPT | |
| SCHEMBL22048290 | 0.77 | NPC1 (0.40) | POLB | |
| SCHEMBL23189194 | 0.76 | PTGES (0.42) | POLBTP53HCAR2LMNAIDH1 | |
| SCHEMBL22048482 | 0.74 | THRB (0.35) | POLBTP53HCAR2THRBLMNA | |
| SCHEMBL20344607 | 0.74 | ALDH1A1 (0.37) | POLBTP53THRBMAPT | |
| SCHEMBL17312615 | 0.74 | RIPK1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |