Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.95 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.61 |
| ▸ | NCF1 | P14598 | 1/20 | 0.61 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48987 | 1.00 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| SCHEMBL30575196 | 1.00 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| SCHEMBL10648775 | 1.00 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27847995 | 0.98 | CHKA (0.91) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| SCHEMBL49273 | 0.97 | CHKA (1.00) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL591914 | 0.95 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| Iodide SCHEMBL14249446 | 0.95 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29467719 | 0.95 | CHKA (0.95) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| SCHEMBL19468905 | 0.92 | CHKA (0.90) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| Pyridine SCHEMBL10356666 | 0.91 | CHKA (0.79) | CHKAADRB2NCF1PLD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220373541-A1 | Tri-functional Crosslinking Reagents | ETH ZURICH (CH) | 2022-11-24 | — | — | US | disclosed |
| US-11385225-B2 | Tri-functional crosslinking reagents | ETH ZURICH (CH) | 2022-07-12 | — | — | US | disclosed |
| EP-3374348-B1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2021-11-24 | — | — | EP | disclosed |
| US-10550093-B2 | Third generation taxoids and methods of using same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-02-04 | — | — | US | disclosed |
| US-20180328922-A1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ETH ZURICH (CH) | 2018-11-15 | — | — | US | disclosed |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2018-07-12 | — | — | US | disclosed |
| US-9766235-B2 | Trifunctional crosslinking reagents | ETH ZURICH (CH) | 2017-09-19 | — | — | US | disclosed |
| EP-2670755-B1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2016-10-12 | — | — | EP | disclosed |
| EP-2942351-B1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2016-10-12 | — | — | EP | disclosed |
| EP-2942351-A1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH Zurich (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-20140011212-A1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZURICH (CH) | 2014-01-09 | — | — | US | disclosed |
| US-7981926-B2 | Fluorotaxoids | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090118355-A1 | Fluorotaxoids | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2009-05-07 | — | — | US | disclosed |
| WO-2007021957-A2 | FLUOROTAXOIDS | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2007-02-22 | — | — | WO | disclosed |
| US-5880284-A | HAVING ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASES-INHIBITING EFFECTS | DR. KARL THOMAE GMBH (DE) | 1999-03-09 | — | — | US | disclosed |
| US-5681841-A | PREVENTION CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118355-A1 | Fluorotaxoids | FAU, ARF5, ARFGEF1 | CHKA 2413/4885ADRB2 3010/4885NCF1 600/4885 |
| US-11385225-B2 | Tri-functional crosslinking reagents | ADGRF1, FCGR3B, FCGR2A | CHKA 2363/4885ADRB2 2712/4885NCF1 1522/4885 |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | CBR3, TUBB3, CBX3 | CHKA 204/4885ADRB2 1348/4885NCF1 1666/4885 |
| US-20220373541-A1 | Tri-functional Crosslinking Reagents | ADGRF1, SIGLEC7, ADGRE5 | CHKA 1156/4885ADRB2 2211/4885NCF1 2279/4885 |
| US-20180328922-A1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ADGRF1, FCGR3B, FCGR2A | CHKA 2363/4885ADRB2 2712/4885NCF1 1522/4885 |
| US-10550093-B2 | Third generation taxoids and methods of using same | CBR3, TUBB3, CBX3 | CHKA 204/4885ADRB2 1348/4885NCF1 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.