Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643542 | 0.88 | CHRNB4 (0.55) | CHRNB4CHRNA3NLRP3RECQLSSTR5 | |
| SCHEMBL2210658 | 0.81 | CHRNB4 (0.36) | CHRNB4CHRNA3NLRP3RECQLTDP1 | |
| SCHEMBL14534188 | 0.74 | CHRNB4 (0.53) | CHRNB4CHRNA3NLRP3RECQLSSTR5 | |
| SCHEMBL14278576 | 0.74 | NLRP3 (0.46) | CHRNB4CHRNA3NLRP3RECQLPOLB | |
| SCHEMBL5015653 | 0.73 | CHRNB4 (0.52) | CHRNB4CHRNA3NLRP3RECQLSSTR5 | |
| SCHEMBL28665635 | 0.72 | NLRP3 (0.55) | CHRNB4CHRNA3NLRP3RECQLPOLB | |
| SCHEMBL4643127 | 0.72 | CHRNB4 (0.40) | CHRNB4CHRNA3 | |
| Ammonia Solution, Strong SCHEMBL5129561 | 0.72 | CHRNB4 (0.51) | CHRNB4CHRNA3NLRP3RECQLSSTR5 | |
| Hydrochloric Acid SCHEMBL3221936 | 0.72 | CHRNB4 (0.51) | CHRNB4CHRNA3NLRP3RECQLSSTR5 | |
| SCHEMBL5012160 | 0.71 | CHRNB4 (0.50) | CHRNB4CHRNA3NLRP3RECQLSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981883-B2 | Substituted spiro-compounds and the use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-07-19 | — | — | US | claimed |
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | claimed |
| US-7981883-B2 | Substituted spiro-compounds and the use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-07-19 | — | — | US | disclosed |
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | REN, PKD1, PKD2 | CHRNB4 4783/4885CHRNA3 4690/4885NLRP3 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.