Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | FAP | Q12884 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909217 | 1.00 | GAA (0.59) | GAAHPGDRORCALDH1A1PIK3CD | |
| SCHEMBL22797018 | 0.91 | ALDH1A1 (0.58) | GAAHPGDRORCALDH1A1PIK3CD | |
| SCHEMBL10770322 | 0.83 | ALDH1A1 (0.51) | GAAALDH1A1PIK3CDPREPFAP | |
| SCHEMBL27937192 | 0.83 | PREP (0.51) | GAAHPGDALDH1A1PIK3CDPREP | |
| SCHEMBL5909319 | 0.82 | VNN1 (0.64) | GAAHPGDRORCALDH1A1MEN1 | |
| SCHEMBL5908997 | 0.82 | GAA (0.71) | GAAHPGDALDH1A1PIK3CDKDM4E | |
| SCHEMBL22055721 | 0.82 | GAA (0.71) | GAAHPGDALDH1A1PIK3CDKDM4E | |
| SCHEMBL2226530 | 0.82 | ALDH1A1 (0.66) | ALDH1A1PREPFAPDPP4DPP8 | |
| SCHEMBL4893223 | 0.82 | ALDH1A1 (0.66) | ALDH1A1PREPFAPDPP4DPP8 | |
| SCHEMBL12812547 | 0.82 | HPGD (0.75) | GAAHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |