Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631240 | 0.83 | CACNA1B (0.43) | PIK3CDPIK3CAPIK3CGRAB9AHSD11B1 | |
| SCHEMBL22055777 | 0.83 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGHSD11B1MAPT | |
| SCHEMBL19280304 | 0.82 | ALDH1A1 (0.58) | PIK3CDPIK3CAPIK3CGMEN1KMT2A | |
| SCHEMBL19701984 | 0.79 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGHSD11B1KCNH2 | |
| SCHEMBL24993539 | 0.74 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL6410939 | 0.73 | HSD11B1 (0.53) | RAB9AMEN1NPC1KMT2AHSD11B1 | |
| SCHEMBL30173082 | 0.72 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CGRAB9AHDAC8 | |
| SCHEMBL17055358 | 0.72 | KMT2A (0.53) | MEN1KMT2AHSD11B1GAADDB1 | |
| SCHEMBL17055357 | 0.70 | POLB (0.53) | PIK3CDPIK3CAPIK3CGRAB9AMAPT | |
| SCHEMBL22055646 | 0.70 | RAB9A (0.52) | RAB9AMEN1NPC1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |